PUFAs & Age-Related Macular Degeneration

By Atom Bergstrom

Atom’s Blog

What do you get when you mix ultraviolet light, oxygen, and polyunsaturated fatty acids?

Age-Related Macular Degeneration.

D. Virgil Alfaro III, et al (Age-Related Macular Degeneration: A Comprehensive Textbook, 2006) wrote …

“Age is the strongest risk factor for AMD [age-related macular degeneration] and correlates with RPE [retinal pigment epithelium] lipofuscin content. For example, at the age of 90, approximately 19% of the RPE cells are occupied by lipofuscin, compared with only 1% in the first 10 years of life. Lipofuscin is a brownish, autofluorescent pigment that accumulates from the breakdown of POS [photoreceptor outer segments] in the lysosomes of the RPE. Lipofuscin is present in many other cell types, including brain, heart muscle, and liver. It is also referred to as the ‘aging’ pigment. Lipofuscin accumulation in the RPE is a hallmark of AMD, and much greater amounts of lipofuscin are seen in atrophic AMD than in normal eyes.

“Photoreceptor loss was found to directly correlate with adjacent RPE lipofuscin accumulation. This finding suggests that the increased phagocytic and metabolic load on the RPE causes an accumulation of lipofuscin in the RPE, resulting in photoceptor death. The photoreceptors likely undergo some oxidation due to the high proportion of the easily oxidized PUFAs and therefore yield changed products that are not easily digested by RPE cells.”

Ray Peat (“Aging Eyes, Infant Eyes, and Excitable Tissues,” RayPeat dot com, 2006-2015) wrote …

“The popular supplements melatonin, tryptophan, fish oils, St. John’s wort, and the various omega-3 oils, all increase the risk of retinal light damage and macular degeneration. Serotonin uptake inhibiting antidepressants are suspected to be able to cause it.”
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    'PUFAs & Age-Related Macular Degeneration' have 3 comments

    1. September 15, 2015 @ 3:09 pm Atom

      Swami Nitty-Gritty quit school after a single day, telling his father Benjamin, “They can’t teach me what I want to learn.”

      Louis L’Amour (1908-1988) dropped out of school because school was interfering with his education.

      At sixteen, L’Amour was already reading over 400 nonfiction books a year, and continued doing so while working at various full-time jobs such as miner, lumberjack, merchant marine, etc.

      Attendance is NOT learning, skill, or competence.

      Instruction is NOT learning, skill, or competence.

      Curriculum is NOT learning, skill, or competence.

      Course structure is NOT learning, skill, or competence.

      When the doors of the Santa Barbara Sun Sync (Open Source) School of Self-Healing & Continuing Education swing open, there will be no diplomas, certificates, credentials, licenses, and/or pedigrees.

      According to Swami Nitty-Gritty …

      “It’s revelation, not visualization. The School of Total Knowledge is the college of your own brain. Books are the long route to it. Dreams are the short-cut route to it. Electromagnetic resonance is the intuitive level independent of the senses. Oxygen is necessary for biophotography of the brain — witnessing atomic elements in the bionic state of continuity.”

      Reply


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