Very Low Thyroid Activity
According to Ray Peat …
“The first effect of too much PUFA is to block the ability of the thyroid gland to secrete the hormone by breaking down the thyroid globulin. If the thyroid does manage to secrete it, the transport of it on proteins in the blood is inhibited in proportion to the unsaturation. Fish oils with 5 and 6 unsaturated double bonds are the most powerful, almost total inhibitors of thyroid transport. Linolenic acid (omega -3) fats with 3 double bonds inhibits about 50%, linoleic acid (omega -6) with 2 double bonds inhibits about 30%. So the inhibition is proportional to the amount of double bonds. The responsiveness of the cell to thyroid is inhibited in proportion to the amount of unsaturated fats. Carotene is highly unsaturated and it has the same effect of interfering with thyroid function because of this series of unsaturations.“
Hubert Richardson, M.D. (The Thyroid and Parathyroid Glands, 1905) wrote …
“Myxedema [very low thyroid activity] in the adult is usually a slowly progressive disease, though cases are on record where it has developed rapidly. Charcot and Ord report cases which commenced with a chill, in one case with hematuria [blood in the urine], developing within a week. Byrom Bramwell states that in one of his cases the disease appeared in a few days after an attack of influenza. It is probable that in these cases the disease had been latent, unobserved by the patient for some time, until some intercurrent disease made a call upon the gland for an increase of secretion to which it was unable to respond.
“The initial symptom is an intense lassitude and debility. Women who have heretofore been bright and active in their duties have a repugnance to exertion both of body and mind. This is associated with an increase of bulk of the body, a dryness of the skin and an increased susceptibility to cold. I have observed that in the very early stages there is a hyperactivity of the sebaceous glands [oil-producing glands], the surface of the skin being greasy, while the head is full of dandruff. Frontal headache is often a cause of complaint in the earliest stages. As the disease advances the face, trunk and limbs increase in bulk with the appearance of edema, except that the skin does not pit on pressure nor does it exude fluid on puncture; there is an appearance as if the skin were too large, hanging in thick folds on various parts of the body. Ordinary dropsy of the feet occurs in about 20 per cent of the cases.”
According to the same source …
“The patients often complain of a tingling or pricking sensation of the skin. The body temperature is subnormal, being 96.5 degrees F. or even a little lower. The subnormal temperature and the susceptibility to cold are due to decreased oxidation and a pathologic condition of the cutaneous capillary system.
“The pulse is slower than normal, soft and weak, the heart’s action feeble, the second sound accentuated, the mean blood pressure increased, the heart dilated, the cardiac muscle degenerated and the arteries atheromatous; in the latter case thyroid feeding must be conducted with caution.”