Fish Oil & Muscular Dystrophy
Anyone praising the virtues of DHA and EPA has to consider the Elephant In the Living Room — Yellow Fat Disease.
DHA and EPA = Yellow Fat Disease and its tag-along afflictions of White Muscle Disease, Mulberry Heart Disease, Brown Atrophy of the Heart, Brown Atrophy of the Liver, Hepatosis Dietetica, Nutritional Muscular Dystrophy, Progressive Lipofuscinosis, etc.
Alejandro Suárez-Bonnet1, Antonio Espinosa de los Monteros, Pedro Herráez, Francisco Rodríguez, Marisa Andrada, & Maria José Caballero (“Fat Embolism Secondary to Yellow Fat Disease in an Appaloosa Horse,” Journal of Veterinary Diagnostic Investigation, Sept. 2008) wrote …
“The first report of yellow fat disease in 1957 described a disease in foals in New Zealand, characterized by muscular dystrophy and inflammation of the adipose tissue. Yellow fat disease, or nutritional panniculitis, is a generalized disorder of fat deposits, characterized by extensive adipose cell degeneration and inflammation. During these processes, a progressive peroxidation of unsaturated fatty acids may occur. Ceroid pigment, which is responsible for the typical yellow discoloration of fat, is the final product of this peroxidation process.”
Lee Russell McDowell (Vitamins in Animal Nutrition: Comparative Aspects to Human Nutrition, 2012) wrote …
“Channel catfish fed a vitamin-E-deficient diet containing oxidized menhaden oil exhibited reduced growth, muscular dystrophy, fatty livers, anemia, exudative diathesis, and depigmentation in 16 weeks (NRC, 1983).”
Vitamin E and (in most cases) selenium protect against long-chain polyunsaturated fatty acids and their peroxidation, but don’t fare very well after the fact.
According to the same source (Lee Russell McDowell) …
“The most universally recognized disease in animals due to vitamin E deficiency is muscular dystrophy. Attempts to demonstrate improvement from vitamin E therapy in humans have failed for the most part (Horwitt, 1980).”
Maybe vitamin E therapy fails because it’s the WRONG TYPE OF VITAMIN E.