Fat-Holding Pigment #1

By Atom Bergstrom

Atom’s Blog

What did we feed our pets and lab animals back in the day?

And cows aren’t always “free of fat-holding pigment.”

I’ve come across this before, so let’s just say that cows are relatively free from lipofuscin.


David H. Dolley & Frances V. Guthrie (“The Pigmentation of Nerve Cells,” The Journal of Medical Research, Sept. 1918) wrote …

“The literature on the dual pigment of nerve cells. — The pigment found in the bodies of nerve cells is usually classified in textbooks of pathology, when classified at all, as a fat-holding, or in a loose sense, lipochrome pigment (Wells, p. 434; Adami, p. 894; Mallory, p. 112; MacCallum, p. 120). However, on reference to the original reports, it is found to be frankly stated by most investigators that the fat-holding pigment is not the only kind. A pigment of the melanin type may exist independently or side by side. The emphasis consequent upon one or more of the specific fatty reactions, aided by certain erroneous inferences as to the identity of the two, has brought the fat-holding group to undue prominence.

“The close association of fat and pigment is, after all, not such a modern idea. Virchow (’47) remarked on certain phases of it, while priority of observation for the nerve cell belongs to Meschede (’65, ’72) under the designation of ‘fatty-pigmentary degeneration.’ Meschede’s description and pictures of the ether-solvent change of the yellow glistening granules to a faded finely granular ground substance, followed in the same cell, are more convincing than some of modern times, though not allowed by his contemporaries to pass unchallenged.

“Rosin (’96), who revived the suggestion of fat combination, distinguished two sorts of pigment. The one is the dark brown, red or red-brown, which it is stated gives the characteristic color to the locus caeruleus, the substantia nigra and other parts; the other is the clear yellow, only lightly colored pigment. The latter he found blackened, in human material only, after the Marchi osmic technic, but unstained after prolonged extraction with alcohol and ether. It is consequently of the nature of a lipochrome. He noted, however, a negative finding which has its corroboration in the present work, that small animals, namely, the dog, the cat, the rabbit, the rat and the mouse, were completely free of fat-holding pigment, though it appeared in small amount in three cows. In a later paper, Rosin and Fenyvessy (’00) presented a demonstration with Sudan III.

“Lubarsch (’02) and his pupil Sehrt (’04) attacked especially the problem of fat-holding pigments occurring in somatic cells, including nerve cells, and it is their work which is mainly responsible for the fat-holding generalization for the nerve cell. These studies were limited to human material. Lubarsch employed Sudan III in demonstration, to which numerous pigments — of brown atrophy of the heart, of the liver, the kidneys, the adrenal, the testicle, the corpus luteum, as well as of the spinal and cœliac ganglia and the substantia nigra — all responded ‘in more or less outspoken manner.’ The reaction became weaker and weaker after fat solvents. These are the ‘wear and tear’ pigments.”


Brown atrophy of the testicle? No thanks!


To Be Continued


Missing Podcast?

If you see an error with an archived podcast or know that an episode of our show is missing, please press the button below to send us a message so we can look into it.

Enter your name and email if you want to be notified when this podcast is fixed:

'Fat-Holding Pigment #1' has no comments

Be the first to comment this post!

Would you like to share your thoughts?

Your email address will not be published.

©Copyright One Radio Network 2019 • All rights reserved. | Site built by RedLotus Austin
The information on this website and talk shows is solely for informational and entertainment purposes. IT IS NOT INTENDED TO PROVIDE MEDICAL ADVICE. Neither the Editors, producers of One Radio Network, Patrick Timpone, their guests or web masters take responsibility for any possible consequences from any treatment, procedure, exercise, dietary modification, action or application of medication which results from reading or following the information contained on this website in written or audio form, live or podcasts. The publication of this information does not constitute the practice of medicine, and this information does not replace the advice of your physician or other health care provider. Before undertaking any course of treatment, the reader must seek the advice of their physician or other health care provider and take total responsibility for his or her actions at all times. Patrick Joseph of the family of Timpone, a man...All rights reserved, without recourse.